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PROJECTS & FUNDING AGENCIES

Projects

  • Title:Consolidation and structuring of competitive research units and other promotion actions
  • Grant Ref. 181-NANOEATERS-1E
  • Partners: Universidade de Vigo
  • Funding: GAIN – Xunta de Galicia
  • Star/End: October 2020 – November 2023

Aid to consolidate, structure and specialize the most competitive research units of the Galician R + D + i System through the modality of competitive reference groups that, due to their scientific production and their R + D activity, constitute a reference in the Galician System of R + D + I

  • Title: Valorization and transfer of NANOtechnologies to EArly adopTERS of the Euroregion Galicia-Norte Portugal- NANOEATERS
  • Grant Ref. 181-NANOEATERS-1E
  • Partners: GAIN, INL, UVIGO, USC, CTAG, AIMEN, FBGS, GRADIANT
  • Funding: POCTEP-UE
  • Star/End: January 2017 / September 2021

NANOeaters is a network of Research Centers that was created with the aim of supporting companies in the Euroregion in the application of value-added nanotechnological solutions, for the definition of new products and/or services, susceptible to commercial exploitation, that offer answers effective to the weaknesses detected in the Smart Specialization Strategy of Euroregion Galicia – North of Portugal. The objective of Gradiant in the project, together with INL and UVigo, is the design, prototyping and evaluation of an ultra-low consumption sensor with communications capacity that combines the latest advances in nanosensors and communications, seeking in turn to exploit the advantages of integrated electronics. This is intended to achieve exceptionally long autonomies when using batteries, or autonomous deployments in case micro-power generation techniques are used instead of the latter. Its application would focus on sectors such as industry or areas of application such as Smart City.

  • Title: Technology Transfer to Reduce Food Risks – FOODSENS
  • Grant Ref. 0591_FOODSENS_1E
  • Partners: ANFACO CECOPESCA, CINBIO, CMEMS, CSIC, ICETA, LEICAR
  • Funding: POCTEP-UE
  • Stard / End: January / April 2022

https://qa.ff.up.pt/foodsens/indexe.php

FoodSENS aims to make a diagnosis of the prevalent food risks in the cross-border region of Galicia-North of Portugal. Evaluate the potential impact of the offer of new analytical tools in the prevention of food accidents. Promote collaboration between the different actors in the agri-food chain through the establishment of a cross-border multidisciplinary network, capable of promoting greater competitiveness and international projection. Develop new analytical sensors to detect some of the main problems in terms of food safety, namely, polycyclic aromatic hydrocarbons (PAHs), bacterial biofilms, allergens, mycotoxins and toxic microalgae, capable of filling the deficiencies of the sector agri-food. The new sensors must be characterized by high levels of speed, sensitivity and specificity, the possibility of miniaturization and automation and the ability to provide results in real time. Carry out an on-site demonstration of the analytical tools developed in the different sectors of the agri-food value chain, in order to evaluate their effectiveness and promote any “improvements” that may be necessary.

  • Title: Advanced Surface Enhanced Raman Spectroscopy (SERS) based technologies for gas and liquids sensING in the area of chemical protection – SERSING
  • Grant Agreement Nº 883390
  • Partners: DANMARKS TEKNISKE UNIVERSITET, UNIVERSITEIT TWENTE, UNIVERSITY OF VIGO, SERSTECH AB, TOTALFORSVARETS FORSKNINGSINSTITUT, STATNI USTAV JADERNE, CHEMICKE A BIOLOGICKE OCHRANY VVI, UNIVERSIDAD DE ZARAGOZA, SILMECO APS, CSIC, IISGS
  • Funding: UE
  • Stard / End: July 2020 – June 2024
  • www.sersing.eu

Rapid detection and identification of chemical hazards can save lives. The EU-funded SERSing project will develop micro-devices that can be integrated into lightweight, portable Raman equipment, aimed at identifying chemical hazards at low concentrations in the liquid and gas phase, as well as in various environments. This ultra-sensitive and reliable laboratory technology on a chip is designed for immediate intervention services and is based on Surface Enhanced Raman Spectroscopy (SERS). It can also be customized to combine geolocation and communication technologies. In addition, the project will allow the installation of the miniaturized platform in robotic units that can be deployed in dangerous situations.

  • Title: Ultrasensitive BIOsensing platform for multiplex CELLular protein PHEnotyping at single-cell level – BIOCELLPHE
  • Grant Agreement Nº 965018
  • Partners: UNIVERSIDADE DE VIGO, UNIVERSIDAD POLITECNICA DE MADRID, INL, CSIC, ISTITUTI CLINICI SCIENTIFICI MAUGERI SOCIETA’ PER AZIONI SOCIETA’ BENEFI, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL, INSTITUT NATIONAL DE RECHERCHE POUR L’AGRICULTURE, L’ALIMENTATION ET L’ENVIRONNEMENT, RUBINANOMED, TEMATYS
  • Funding: UE
  • Stard / End: May 2021 – April 2025
  • www.biocellphe.eu

BIOCELLPHE provides frontier scientific and technological advancements to generate a breakthrough technology realizing the identification of proteins (i.e. phenotyping) as diagnostic biomarkers at single-cell level with unmatched sensitivity, multiplexing capabilities and portability. BIOCELLPHE proposes the generation of engineered bacteria able to recognize and bind to specific protein targets on the surface of circulating tumor cells (CTCs) responsible for cancer metastasis, thereby triggering the production of chemical signals that can be detected simultaneously, and with extremely high sensitivity by surface-enhanced Raman scattering (SERS). SERS is a powerful analytical technique that employs plasmonic nanoparticles as optical enhancers for ultrasensitive chemical analysis achieving single-molecule detection level. BIOCELLPHE will implement these advancements toward the generation of an optofluidic lab-on-a-chip SERS device enabling ultrasensitive identification and multiplex phenotyping of CTCs. We anticipate that BIOCELLPHE long-term vision and scientific breakthrough will lead to a sky limit technology that will be widely applicable, not only in the diagnostic arena, but also in many other applications (e.g. biomedical, environmental). No one has previously been able to attempt this vision due to current challenges and technical limitations, but we believe to be in a position to pave a way for achieving this now. To realize this highly ambitious project, BIOCELLPHE gathers a highly multidisciplinary community of leading experts in synthetic biology, nanotechnology, plasmonics, microfluidics, artificial intelligence, and cancer diagnosis. We believe that successful deployment of BIOCELLPHE has the potential to usher in a new era of medical diagnostics and it will provide new paradigms in biology and biomedicine, advancing frontier science and technologies at the European academic and industrial sectors.

  • Title: Development of lab-on-a-chip nanostructured sensors for the detection of foodborne pathogens based on surface-augmented Raman spectroscopy (SERS)
  • Partners: Universidade de Vigo
  • Funding: Fundacion Ramon Areces
  • Stard / End: March 2017- April 2021

The main objective of the SERSforSAFETY project is to design and develop miniaturized “lab-on-chip” diagnostic platforms based on surface-enhanced Raman spectroscopy for the subsequent fabrication of fast, portable point-of-care devices that ultra-detect bacteria and various chemical pollutants. To achieve our objectives, we will apply synthetic methodologies developed in the fields of Nanochemistry and Materials Science since the diagnostic platforms will be based on sets of metallic plasmonic nanoparticles (Au mainly) deposited on porous filter membranes (such as paper) or on substrates of glass designed by soft photolithography techniques. Once the materials have been manufactured, the next objective is to demonstrate their applicability in the field of sensors, and in particular towards the biosensing of different analytes in complex media such as food.
To do this, their ability to detect different pathogenic microorganisms and chemical contaminants will be evaluated using SERS spectroscopy. Finally, we will address the main objective of the project: the development of a miniaturized “lab-on-chip” diagnostic platform and its application in point-of-care devices for the ultradetection of pathogenic microorganisms and chemical contaminants in real samples. At the current stage, we are developing a lab on a chip system based on a lateral flow immunoassay for the simultaneous detection of different allergens and contaminants. For this, different metallic nanoparticles encoded with active Raman molecules have been synthesized, which will bioconjuginate with specific antibodies to the allergens and pollutants to be detected.

  • Title: A rapid non invasive on-chip MiRNA based Sputum assay for early stage Lung Cancer screening – MI-SCAN
  • Grant Agreement Nº 894227
  • Partners: Universidade de Vigo
  • Funding: UE
  • Stard / End: April 2021 – March 2023

Lung cancer is responsible for the majority of cancer deaths in the world. Although most lung tumors are not as aggressive as non-small cell lung carcinoma (NSCLC), a late diagnosis leads to a dire outcome. The EU-funded MI-SCAN project aims to improve non-invasive detection of lung cancer in early stages (I, II) using miRNA biomarkers. The scientists will develop a microfluidic device that will use miRNA probes combined with gold nanoparticles to capture the miRNA biomarkers present in lung cancer cells. An Enhanced Surface Raman Spectrometry (SERS) approach is applied to achieve sensitive detection. This biosensor works with non-invasive sputum samples, thus exceeding the methods most used today for the diagnosis of lung cancer, which are invasive and time-consuming.

  • Title: SERS based lteral flow point of care inmunoassay for ultrasensitive detection of SARS-COVID-2 – SERSforSARS
  • Partners: Universidade de Vigo
  • Funding: CRUE – Banco Santander
  • Stard / End: July 2020 – December 2021

SERSforSARS shall combine molecular biology, nanotechnology and SERS to develop a LFIA test for ultrasensitive PoC identification of SARS-CoV-2 in nasopharyngeal biofluids by means of SERS-nanotags generated against nucleocapsid (N) and spike (S) proteins of SARS-CoV2 simultaneously. These viral antigens have been shown to elicit immunoglobulin (Ig) M and IgG antibodies.

Grant PID2019-108954RB-I00 funded by:

  • Title: Rational Design of High Efficiency SERS TAG for Detection by Immunoassay and Bioimaging – TAGSING
  • Partners: Universidade de Vigo
  • Funding: Ministerio de Ciencia e Innovación
  • Stard / End: June 2020 – May 2023

The TAGSING project’s general objective is the rational design, manufacture and careful characterization of high-performance SERS encoded nanoparticles (SERS tags) to overcome certain aspects/drawbacks with limits the development of point of care (PoC) immunoassays based on SERS (multiplex capabilities in lateral-flow immunoassay, or false positives in sandwich-type immunoassay) and to contribute to the development of new in vitro strategies of bioimaging (such as, SERS based bioimaging using bacterial cells combined with SERS tags). This project is presented in the context of research that PIs have developed over the past 20 years related to the synthesis, characterization and surface modification of plasmonic nanoparticles and their applications in biosensing. In this proposal, we present a multidisciplinary approach as it encompasses the design and development of plasmonic nanostructures with well-defined optical properties, the structural, compositional and optical characterization, the fabrication of SERS tags libraries and characterization of their SERS efficiency and the application of the SERS tags in SERS-based immunoassay and for in vitro monitoring of different aspects of the bacterial infection process to human cancer cells. The combination of such a cutting-edge technology in interdisciplinary fields such as Chemistry, Materials Science, Nanotechnology and Biomedicine is expected to provide impactful results to the Spanish and European research, technological, development and innovation system. Fulfilling the requirements of the Retos de la Sociedad Health identified within the Spanish Strategy for Science and Technology and Innovation 2013-2020, as well as the Key Enabling Technologies, and more precisely Nanotechnology and Advanced Materials. The results and innovations that are expected will significantly advance the state of the art in the synthesis of high-performance SERS tags, in the fabrication of plasmonic nanostructures and more importantly will contribute to promote SERS-based technology from proof-of-concept research works to commercially available analytical and bioimaging tools.

Funding Agencies